发明公开
EP1223169A1 Agent for potentiating nerve growth factor activity containg 1,2-ethanediol derivate or salt thereof
失效
含有活性物质对促进神经生长因子和其盐1,2-乙二醇衍生物
- 专利标题： Agent for potentiating nerve growth factor activity containg 1,2-ethanediol derivate or salt thereof
- 专利标题（中）： 含有活性物质对促进神经生长因子和其盐1,2-乙二醇衍生物
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申请号： EP02004782.5申请日： 1995-10-20
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公开(公告)号： EP1223169A1公开(公告)日： 2002-07-17
- 发明人: Ono, Satoshi , Maekawa, Mutsuko , Narita, Hirokazu , Hirata, Kazunari
- 申请人： TOYAMA CHEMICAL CO., LTD.
- 申请人地址： 2-5, 3-chome, Nishishinjuku, Shinjuku-ku Tokyo JP
- 专利权人： TOYAMA CHEMICAL CO., LTD.
- 当前专利权人： TOYAMA CHEMICAL CO., LTD.
- 当前专利权人地址： 2-5, 3-chome, Nishishinjuku, Shinjuku-ku Tokyo JP
- 代理机构： Wächtershäuser, Günter, Prof. Dr.
- 优先权： JP28427294 19941025; JP28427394 19941025
- 主分类号： C07D333/54
- IPC分类号： C07D333/54 ; C07D307/79 ; C07D417/12 ; C07C217/10 ; A61K31/38 ; A61K31/34 ; A61K31/495 ; A61K31/44 ; A61K31/535 ; A61K31/40
摘要：
A remedy for diseases caused by degeneration of central nervous system, comprising a 1,2-ethanediol derivative represented by the following general formula or its salt:
wherein R 1 represents a substituted or unsubstituted phenyl, naphthyl, indanyl, indenyl, tetrahydronaphthyl or heterocyclic group; R 2 represents a hydrogen atom, a C 1-6 alkyl group or a hydroxyl-protecting group; R 3 represents a hydrogen atom or a C 1-6 alkyl group; nR 4 's may be the same as or different from one another and each represents a hydrogen atom or a C 1-6 alkyl group; nR 5' s may be the same as or different from one another and each represents a hydrogen atom or a C 1-6 alkyl group; R 6 represents a substituted or unsubstituted amino or nitrogen-containing heterocyclic group or an ammonio group; and n represents 0 or an integer of 1 to 6, provided that the following 1,2-ethanediol derivative represented by general formula or its salt:
wherein nR 1a 'S may be the same as or different from one another and each represents a fluorine, chlorine, bromine or iodine atom, C 1-6 alkyl, C 1-6 alkoxy or phenyl group; R 2a represents a hydrogen atom or a hydroxyl-protecting group; R 6a represents a C 1-6 alkyl-substituted amino group or a pyrrolyl, pyrrolidinyl, piperidyl, piperazinyl, imidazolyl, pyrazolyl, pyridyl, tetrahydropyridyl, pyrimidinyl, morpholinyl, thiomorpholinyl, quinolyl, quinolidinyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, quinuclidinyl, thiazolyl, tetrazolyl, thiadiazolyl, pyrrolinyl, imidazolinyl, imidazolidinyl, pyrazolinyl, pyrazolidinyl, purinyl, indazolyl, furyl, thienyl, benzothienyl, pyranyl, isobenzofuranyl, oxazolyl, benzofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, quinoxalyl, dihydroquinoxalinyl, 2,3-dihydrobenzothienyl, 2,3-dihydrobenzopyrrolyl, 2,3-dihydro-4H-1-thianaphthyl, 2,3-dihydrobenzofuranyl, benzo[b]dioxanyl, imidazo[2,3-a]pyridyl, benzo[b]piperazinyl, chromenyl, isothiazolyl, isoxazolyl, thiadiazolyl, oxadiazolyl, pyridazinyl, isoindolyl or isoquinolyl group; and n represents an integer of 1 to 5, is excluded.
wherein R 1 represents a substituted or unsubstituted phenyl, naphthyl, indanyl, indenyl, tetrahydronaphthyl or heterocyclic group; R 2 represents a hydrogen atom, a C 1-6 alkyl group or a hydroxyl-protecting group; R 3 represents a hydrogen atom or a C 1-6 alkyl group; nR 4 's may be the same as or different from one another and each represents a hydrogen atom or a C 1-6 alkyl group; nR 5' s may be the same as or different from one another and each represents a hydrogen atom or a C 1-6 alkyl group; R 6 represents a substituted or unsubstituted amino or nitrogen-containing heterocyclic group or an ammonio group; and n represents 0 or an integer of 1 to 6, provided that the following 1,2-ethanediol derivative represented by general formula or its salt:
wherein nR 1a 'S may be the same as or different from one another and each represents a fluorine, chlorine, bromine or iodine atom, C 1-6 alkyl, C 1-6 alkoxy or phenyl group; R 2a represents a hydrogen atom or a hydroxyl-protecting group; R 6a represents a C 1-6 alkyl-substituted amino group or a pyrrolyl, pyrrolidinyl, piperidyl, piperazinyl, imidazolyl, pyrazolyl, pyridyl, tetrahydropyridyl, pyrimidinyl, morpholinyl, thiomorpholinyl, quinolyl, quinolidinyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, quinuclidinyl, thiazolyl, tetrazolyl, thiadiazolyl, pyrrolinyl, imidazolinyl, imidazolidinyl, pyrazolinyl, pyrazolidinyl, purinyl, indazolyl, furyl, thienyl, benzothienyl, pyranyl, isobenzofuranyl, oxazolyl, benzofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, quinoxalyl, dihydroquinoxalinyl, 2,3-dihydrobenzothienyl, 2,3-dihydrobenzopyrrolyl, 2,3-dihydro-4H-1-thianaphthyl, 2,3-dihydrobenzofuranyl, benzo[b]dioxanyl, imidazo[2,3-a]pyridyl, benzo[b]piperazinyl, chromenyl, isothiazolyl, isoxazolyl, thiadiazolyl, oxadiazolyl, pyridazinyl, isoindolyl or isoquinolyl group; and n represents an integer of 1 to 5, is excluded.
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