发明公开
- 专利标题： PROCESSES FOR THE PREPARATION OF SUMATRIPTAN AND RELATED COMPOUNDS
- 专利标题（中）： 用于生产舒马曲坦和类似化合物
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申请号： EP00972875.9申请日： 2000-10-27
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公开(公告)号： EP1226116A1公开(公告)日： 2002-07-31
- 发明人: HOLMAN, Nicholas, John , FRIEND, Christopher, Lyndon
- 申请人： BASF AKTIENGESELLSCHAFT
- 申请人地址： 67056 Ludwigshafen DE
- 专利权人： BASF AKTIENGESELLSCHAFT
- 当前专利权人： BASF AKTIENGESELLSCHAFT
- 当前专利权人地址： 67056 Ludwigshafen DE
- 优先权： GB9926250 19991106
- 国际公布： WO0134561 20010517
- 主分类号： C07C303/40
- IPC分类号： C07C303/40 ; C07C311/35 ; C07D209/14
摘要：
The present invention relates to a process for preparing phenylhydrazines of formula (I) in which R represents CH2SO2NHCH3, CH2CH2SO2Ph, CH2CH2SO2NHMe or a group of structure (A), (B), (C), in which a diazonium salt of formula (II) in which X represents an anion derived from hydrochloric acid, sulphuric acid, acetic acid, phosphoric acid, tetrafluoroboric acid or hydrobromic acid is reduced by a dithionite salt. The resulting phenylhydrazines can be converted to the corresponding indole derivatives by the Fischer indole synthesis.
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