发明公开
EP1232254A1 PROCESS FOR THE PRODUCTION OF A REVERSIBLY INACTIVE ACIDIFIED PLASMIN COMPOSITION
有权
方法生产可逆不活跃，酸化PLASMINZUSAMMENSETZUNG
- 专利标题： PROCESS FOR THE PRODUCTION OF A REVERSIBLY INACTIVE ACIDIFIED PLASMIN COMPOSITION
- 专利标题（中）： 方法生产可逆不活跃，酸化PLASMINZUSAMMENSETZUNG
-
申请号： EP00991956.4申请日： 2000-11-13
-
公开(公告)号： EP1232254A1公开(公告)日： 2002-08-21
- 发明人: DADD, Christopher , STENLAND, Christopher, J. , KENT, Jonathan, D. , KORNEYEVA, Marina, N. , BAUMBACH, George, A. , COOK, Scott, A. , BRADLEY, Rita, T. , NOVOKHATNY, Valery , VILLINES, Tanette, B.
- 申请人： Bayer Corporation
- 申请人地址： 100 Bayer Road Pittsburgh, PA 15205 US
- 专利权人： Bayer Corporation
- 当前专利权人： Bayer Corporation
- 当前专利权人地址： 100 Bayer Road Pittsburgh, PA 15205 US
- 代理机构： Burkert, Frank
- 优先权： US438331 19991113
- 国际公布： WO01036611 20010525
- 主分类号： C12N9/68
- IPC分类号： C12N9/68 ; A61K38/48
摘要：
The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.
公开/授权文献
信息查询
IPC分类:
