发明公开
- 专利标题： CALCIUM SALTS OF 1,5-BENZODIAZEPINE DERIVATIVES, PROCESS FOR PRODUCING THE SALTS AND DRUGS CONTAINING THE SAME
- 专利标题（中）： 1,5-苯二氮类衍生物钙盐法生产和含有药物
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申请号： EP00979047.8申请日： 2000-12-01
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公开(公告)号： EP1234818A1公开(公告)日： 2002-08-28
- 发明人: SHINOZAKI, Katsuo, Zeria Pharmaceutical Co., Ltd. , MURATA, Masakazu, Zeria Pharmaceutical Co., Ltd. , MAEDA, Kiyoto, Zeria Pharmaceutical Co., Ltd. , TAGUCHI, Hiroaki, Zeria Pharmaceutical Co., Ltd. , KAWASE, Nobuo, Zeria Pharmaceutical Co., Ltd. , MIURA, Naoyoshi, Zeria Pharmaceutical Co., Ltd.
- 申请人： Zeria Pharmaceutical Co., Ltd.
- 申请人地址： 10-11, Nihonbashi Kobuna-cho, Chuo-ku Tokyo 103-8351 JP
- 专利权人： Zeria Pharmaceutical Co., Ltd.
- 当前专利权人： Zeria Pharmaceutical Co., Ltd.
- 当前专利权人地址： 10-11, Nihonbashi Kobuna-cho, Chuo-ku Tokyo 103-8351 JP
- 代理机构： Wächtershäuser, Günter, Prof. Dr.
- 优先权： JP342799 19991202
- 国际公布： WO01040197 20010607
- 主分类号： C07D243/12
- IPC分类号： C07D243/12 ; A61K31/551 ; A61P1/04
摘要：
Provided are calcium salts of a 1,5-benzodiazepine derivative represented by the following formula (I):
(wherein, R 1 represents a lower alkyl group, R 2 represents a phenyl or cyclohexyl group, and Y represents a single bond or a lower alkylene group); a process for preparing the salts; and drugs containing the same as the active ingredient.
The compounds exhibit a potent inhibitory activity against the secretion of gastric acid and potent antagonism against gastrin and/or CCK-B receptor.
(wherein, R 1 represents a lower alkyl group, R 2 represents a phenyl or cyclohexyl group, and Y represents a single bond or a lower alkylene group); a process for preparing the salts; and drugs containing the same as the active ingredient.
The compounds exhibit a potent inhibitory activity against the secretion of gastric acid and potent antagonism against gastrin and/or CCK-B receptor.
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