发明公开
- 专利标题： ALKALI METAL SALT OF THIAZOLIDINE-2,4-DIONE DERIVATIVE
- 专利标题（中）： 碱金属硫脲嘧啶-2,4-二酮衍生物
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申请号： EP01948982.2申请日： 2001-01-30
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公开(公告)号： EP1253145A1公开(公告)日： 2002-10-30
- 发明人: OHNODA, Michiro , ORITA, Kazuo , YOSHIDA, Noriyuki
- 申请人： KYORIN PHARMACEUTICAL CO., LTD.
- 申请人地址： 5, Kanda Surugadai 2-chome Chiyoda-ku, Tokyo 101-0062 JP
- 专利权人： KYORIN PHARMACEUTICAL CO., LTD.
- 当前专利权人： KYORIN PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 5, Kanda Surugadai 2-chome Chiyoda-ku, Tokyo 101-0062 JP
- 代理机构： Merkle, Gebhard
- 优先权： JP2000023610 20000201
- 国际公布： WO01057007 20010809
- 主分类号： C07D277/34
- IPC分类号： C07D277/34
摘要：
The invention provides alkali metal salt of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy- N -[[4-(trifluoromethyl) phenyl]methyl]benzamide and its hydrate. A method has been found, wherein, upon preparing KRP-297, the alkali metal salt of KRP-297 and its hydrate are formed in the reaction system and, after separation and purification, they are freed again from salt, thereby KRP-297 can be advantageously purified industrially for preparation.
公开/授权文献
- EP1253145B1 ALKALI METAL SALT OF THIAZOLIDINE-2,4-DIONE DERIVATIVES 公开/授权日：2006-09-20
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