发明公开
- 专利标题： NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES
- 专利标题（中）： 核酸，蛋白质和抗体
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申请号： EP01912658.0申请日： 2001-01-17
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公开(公告)号： EP1254248A2公开(公告)日： 2002-11-06
- 发明人: ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
- 申请人： Human Genome Sciences, Inc.
- 申请人地址： 9410 Key West Avenue Rockville, MD 20850 US
- 专利权人： Human Genome Sciences, Inc.
- 当前专利权人： Human Genome Sciences, Inc.
- 当前专利权人地址： 9410 Key West Avenue Rockville, MD 20850 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US246613P 20001108; US246609P 20001108; US246478P 20001108; US246524P 20001108; US246523P 20001108; US249299P 20001117; US249210P 20001117; US249216P 20001117; US249217P 20001117; US249211P 20001117; US249215P 20001117; US249218P 20001117; US249208P 20001117; US249213P 20001117; US249212P 20001117; US249207P 20001117; US249245P 20001117; US249244P 20001117; US249297P 20001117; US249214P 20001117; US249264P 20001117; US249209P 20001117; US249300P 20001117; US249265P 20001117; US250391P 20001201; US250160P 20001201; US256719P 20001205; US251030P 20001205; US251988P 20001205; US251479P 20001206; US251869P 20001208; US251856P 20001208; US251868P 20001208; US251990P 20001208; US251989P 20001208; US254097P 20001211; US259678P 20010105; US179065P 20000131; US180628P 20000204; US184664P 20000224; US186350P 20000302; US189874P 20000316; US190076P 20000317; US198123P 20000418; US205515P 20000519; US209467P 20000607; US214886P 20000628; US215135P 20000630; US216647P 20000707; US216880P 20000707; US217487P 20000711; US217496P 20000711; US218290P 20000714; US220963P 20000726; US220964P 20000726; US225757P 20000814; US225270P 20000814; US225447P 20000814; US225267P 20000814; US225758P 20000814; US225268P 20000814; US224518P 20000814; US224519P 20000814; US225759P 20000814; US225213P 20000814; US225266P 20000814; US225214P 20000814; US226279P 20000818; US226868P 20000822; US227182P 20000822; US226681P 20000822; US227009P 20000823; US228924P 20000830; US229344P 20000901; US229343P 20000901; US229287P 20000901; US229345P 20000901; US229513P 20000905; US229509P 20000905; US230438P 20000906; US230437P 20000906; US231413P 20000908; US232080P 20000908; US231414P 20000908; US231244P 20000908; US232081P 20000908; US231242P 20000908; US231243P 20000908; US231968P 20000912; US232401P 20000914; US232399P 20000914; US232400P 20000914; US232397P 20000914; US233063P 20000914; US233064P 20000914; US233065P 20000914; US232398P 20000914; US234223P 20000921; US234274P 20000921; US234997P 20000925; US234998P 20000925; US235484P 20000926; US235834P 20000927; US235836P 20000927; US236369P 20000929; US236327P 20000929; US236370P 20000929; US236368P 20000929; US236367P 20000929; US237039P 20001002; US237038P 20001002; US237040P 20001002; US237037P 20001002; US236802P 20001002; US239937P 20001013; US239935P 20001013; US241785P 20001020; US241809P 20001020; US240960P 20001020; US241787P 20001020; US241808P 20001020; US241221P 20001020; US241786P 20001020; US241826P 20001020; US244617P 20001101; US246474P 20001108; US246532P 20001108; US246476P 20001108; US246526P 20001108; US246475P 20001108; US246525P 20001108; US246528P 20001108; US246527P 20001108; US246477P 20001108; US246611P 20001108; US246610P 20001108
- 国际公布： WO01055325 20010802
- 主分类号： C12P21/06
- IPC分类号： C12P21/06
摘要：
The present invention relates to novel ovarian and/or breast cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'ovarian and/or breast cancer antigens', and the use of such ovarian and/or breast cancer antigens for detecting disorders of the ovaries and/or breast, particularly the presence of ovarian and/or breast cancer and ovarian and/or breast cancer metastases. More specifically, isolated ovarian and/or breast cancer associated nucleic acid molecules are provided encoding novel ovarian and/or breast cancer associated polypeptides. Novel ovarian and/or breast cancer polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human ovarian and/or breast cancer associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the ovaries and/or breast, including ovarian and/or breast cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
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