发明授权
EP1259234B9 3-HETEROARYLIDENYL-2-INDOLINONE COMPOUNDS FOR MODULATING PROTEIN KINASE ACTIVITY AND FOR USE IN CANCER CHEMOTHERAPY
有权
蛋白激酶调节活性AND FOR USE IN癌症化疗3- heteroarylidenyl -2-二氢吲哚衍生物
- 专利标题： 3-HETEROARYLIDENYL-2-INDOLINONE COMPOUNDS FOR MODULATING PROTEIN KINASE ACTIVITY AND FOR USE IN CANCER CHEMOTHERAPY
- 专利标题（中）： 蛋白激酶调节活性AND FOR USE IN癌症化疗3- heteroarylidenyl -2-二氢吲哚衍生物
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申请号： EP00943334.3申请日： 2000-06-30
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公开(公告)号： EP1259234B9公开(公告)日： 2007-02-14
- 发明人: LANGECKER, Peter, J. , SHAWVER, Laura, K. , TANG, Peng, C. , SUN, Li
- 申请人： Sugen, Inc.
- 申请人地址： 230 East Grand Avenue South San Francisco, CA 94080-4811 US
- 专利权人： Sugen, Inc.
- 当前专利权人： Sugen, Inc.
- 当前专利权人地址： 230 East Grand Avenue South San Francisco, CA 94080-4811 US
- 代理机构： Viering, Jentschura & Partner
- 优先权： US476232 19991230; PCT/US99/31232 19991230; US569545 20000512
- 国际公布： WO2001049287 20010712
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61P35/00 ; C07D403/06 ; C07D487/04 ; C07D209/00
摘要：
The present invention relates to 3-heteroarylidenyl-2-indolinone compounds that modulate the enzymatic activity of protein kinases and therefore are expected to be useful in the prevention and tratment of protein kinase related cellular disorders such as cancer. Furthermore, these compounds are expected to enhance the efficacy of other chemotherapeutic agensts, in particular, fluorinated pyrimidines, in the treatment of cancer.
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