发明授权
EP1268761B1 HUMAN UROTHELIAL CELL SPECIFIC UROPLAKIN TRANSCRIPTIONAL REGULATORY SEQUENCES, VECTORS COMPRISING THE SAME, AND METHODS OF USE THEREOF
有权
转录UROPLAKINS谁的载体和使用方法对人体的细胞特异性尿路上皮调控序列
- 专利标题： HUMAN UROTHELIAL CELL SPECIFIC UROPLAKIN TRANSCRIPTIONAL REGULATORY SEQUENCES, VECTORS COMPRISING THE SAME, AND METHODS OF USE THEREOF
- 专利标题（中）： 转录UROPLAKINS谁的载体和使用方法对人体的细胞特异性尿路上皮调控序列
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申请号： EP01918927.3申请日： 2001-03-21
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公开(公告)号： EP1268761B1公开(公告)日： 2008-12-31
- 发明人: YU, De-Chao , ZHANG, Hong , HENDERSON, Daniel, R.
- 申请人： CELL GENESYS, INC.
- 申请人地址： 500 Forbes Boulevard South San Francisco, CA 94080 US
- 专利权人： CELL GENESYS, INC.
- 当前专利权人： CELL GENESYS, INC.
- 当前专利权人地址： 500 Forbes Boulevard South San Francisco, CA 94080 US
- 代理机构： Campbell, Patrick John Henry
- 优先权： US191861P 20000324
- 国际公布： WO2001072994 20011004
- 主分类号： C12N15/00
- IPC分类号： C12N15/00
摘要：
The invention provides new urothelial cell specific transcriptional regulatory sequences derived from human uroplakin II hUPII, as well as polynucleotide constructs such as adenoviral vectors and methods of using hUPII-derived TREs. Additionally, the invention provides adenoviral vectors comprising a gene, preferably an adenovirus gene, under transcriptional control of a urothelial cell-specific transcriptional regulatory element (TRE). These vectors display urothelial cell-specific cytotoxicity, which is especially useful in the context of bladder cancer, in which destruction of these cells is desirable. The invention further provides compositions and host cells comprising the vectors, as well as method of using the adenoviral vectors.
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