发明公开
- 专利标题： 4-FLUORALKYL-2H-BENZOPYRANE MIT ANTIESTROGENER WIRKSAMKEIT
- 专利标题（英）： 4-fluoroalkyl-2h-benzopyrans with anti-estrogenic activity
- 专利标题（中）： 抗雌激素与动作4-氟代-2H-苯并吡喃
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申请号： EP01915345.1申请日： 2001-03-15
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公开(公告)号： EP1272481A1公开(公告)日： 2003-01-08
- 发明人: KÜNZER, Hermann , JAUTELAT, Rolf , ZORN, Ludwig , HEGELE-HARTUNG, Christa , KOLLENKIRCHEN, Uwe , FRITZEMEIER, Karl-Heinrich
- 申请人： SCHERING AKTIENGESELLSCHAFT
- 申请人地址： Müllerstrasse 178 13342 Berlin DE
- 专利权人： SCHERING AKTIENGESELLSCHAFT
- 当前专利权人： SCHERING AKTIENGESELLSCHAFT
- 当前专利权人地址： Müllerstrasse 178 13342 Berlin DE
- 优先权： DE10013782 20000315
- 国际公布： WO01068634 20010920
- 主分类号： C07D311/60
- IPC分类号： C07D311/60 ; A61K31/35 ; A61P5/00
摘要：
The invention relates to novel 4-fluoroalkyl-2H-benzopyrans of the general formula (I), wherein Z is an at least monofluorinated, straight-chained or branched alkyl group with up to 5 carbon atoms, preferably a trifluoromethyl group, and R1, R2, X, Y and n are defined as in the description. The novel compounds have a potent anti-estrogenic activity. They may further have a tissue-selective estrogenic activity. The inventive substances are used in the production of medicaments, especially for treating estrogen-associated diseases and tumors, and of medicaments for hormone replacement therapy (HRT) and for the prevention and treatment of osteoporosis.
公开/授权文献
- EP1272481B1 4-FLUORALKYL-2H-BENZOPYRANE MIT ANTIESTROGENER WIRKSAMKEIT 公开/授权日：2004-04-21
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