发明公开
EP1274717A1 COMPOUNDS AND METHODS FOR LOWERING CHOLESTEROL LEVELS WITHOUT INDUCING HYPERTRIGLYCERIDEMIA
有权
化合物和方法降低胆固醇MIRROR时不感应高甘油三酯血症
- 专利标题： COMPOUNDS AND METHODS FOR LOWERING CHOLESTEROL LEVELS WITHOUT INDUCING HYPERTRIGLYCERIDEMIA
- 专利标题（中）： 化合物和方法降低胆固醇MIRROR时不感应高甘油三酯血症
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申请号： EP01926716.0申请日： 2001-04-06
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公开(公告)号： EP1274717A1公开(公告)日： 2003-01-15
- 发明人: ZANNIS, Vassilis, I. , KYPREOS, Kyriakos, E.
- 申请人： KOS PHARMACEUTICALS, INC. , TRUSTEES OF BOSTON UNIVERSITY
- 申请人地址： Suite 2502,1001 Brickell Bay Drive Miami, FL 33131 US
- 专利权人： KOS PHARMACEUTICALS, INC.,TRUSTEES OF BOSTON UNIVERSITY
- 当前专利权人： KOS PHARMACEUTICALS, INC.,TRUSTEES OF BOSTON UNIVERSITY
- 当前专利权人地址： Suite 2502,1001 Brickell Bay Drive Miami, FL 33131 US
- 代理机构： Grund, Martin, Dr.
- 优先权： US544386 20000406; US679088 20001004; US827854 20010405
- 国际公布： WO01077136 20011018
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; A61K48/00 ; A61K38/00 ; C12N5/00 ; C12N5/08 ; C12N15/00 ; C12N15/63 ; C12N15/86 ; C12N15/88
摘要：
This invention provides methods of lowering cholesterol, delaying the onset of atherosclerosis, or treating atherosclerosis in a mammal without inducing hypertriglyceridemia. These methods involve administering to or expressing in a mammal, an apoE polypeptide or nucleic acid that, when administered to or expressed in a mammal, lowers the total serum cholesterol level without inducing hypertriglyceridemia.
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