发明公开
- 专利标题: PYRROLIDINE AND PIPERIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
- 专利标题(中): 吡咯烷和哌啶衍生物神经退行性疾病的治疗
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申请号: EP01940321.1申请日: 2001-04-11
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公开(公告)号: EP1278728A1公开(公告)日: 2003-01-29
- 发明人: ALANINE, Alexander , BUETTELMANN, Bernd , HEITZ NEIDHART, Marie-Paule , JAESCHKE, Georg , PINARD, Emmanuel , WYLER, Rene
- 申请人: F. HOFFMANN-LA ROCHE AG
- 申请人地址: Grenzacherstrasse 124 4070 Basel CH
- 专利权人: F. HOFFMANN-LA ROCHE AG
- 当前专利权人: F. HOFFMANN-LA ROCHE AG
- 当前专利权人地址: Grenzacherstrasse 124 4070 Basel CH
- 代理机构: Poppe, Regina
- 优先权: EP00108610 20000420
- 国际公布: WO01081303 20011101
- 主分类号: C07D207/12
- IPC分类号: C07D207/12 ; C07D211/54 ; C07D231/56 ; C07D263/58 ; C07D209/34 ; C07D205/04 ; A61K31/40 ; A61K31/44 ; A61K31/395 ; A61P25/28
摘要:
The invention relates to compounds of formula (I) wherein Ar1 is pyridyl or phenyl, substituted by hydroxy, lower alkyl, halogen, amino, nitro, benzyloxy or lower alkoxy-lower alkoxy, or is the group (a) wherein Z1 is a five membered heterocyclic ring, which contains one or two heteroatoms, selected from N or O; R1 is hydrogen, hydroxy or an oxo group; Ar2 is pyridyl or phenyl, optionally substituted by hydroxy, lower alkyl, halogen, amino, nitro, benzyloxy or lower alkoxy-lower alkoxy, or is the group (b) wherein Z2 is a five or six membered ring, which optionally contains one or two heteroatoms, selected from N or O; and Q is -S-, -S(O)- or -S(O)¿2?-; X is a bond, -CH(OH)- or -(CH2)n-; A is a bond or -(CHR)m-; R is hydrogen, halogen or hydroxy, independently from each other if m is 2 or 3; Y is -(CR2)m-, -O-, -C=C-, -C C-, piperidin-1-yl, pyrrolidin-1yl or C4-C6-cycloalkyl, which rings are optionally substituted by hydroxy; B is a bond, -O- or -(CHR)m; n is 1 or 2; and m is 1 to 3 and pharmaceutically acceptable acid addition salts thereof with the exception of compounds, wherein A and B are simultaneously a bond and Y is -CHR-. The compounds may be used in the treatment of neurodegenerative diseases.
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