发明授权
EP1278758B1 Combretastatin A-1 phosphate and Combretastatin B-1 phosphate prodrugs
有权
考布他汀A-1和磷酸考布他汀B-1磷酸盐的前体药物
- 专利标题： Combretastatin A-1 phosphate and Combretastatin B-1 phosphate prodrugs
- 专利标题（中）： 考布他汀A-1和磷酸考布他汀B-1磷酸盐的前体药物
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申请号： EP01928978.4申请日： 2001-04-27
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公开(公告)号： EP1278758B1公开(公告)日： 2011-10-05
- 发明人: PETTIT, George, R. , LIPPERT, John, W., III
- 申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA acting for and on behalf of ARIZONA STATE UNIVERSITY
- 申请人地址： Tempe, AZ 85287 US
- 专利权人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA acting for and on behalf of ARIZONA STATE UNIVERSITY
- 当前专利权人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA acting for and on behalf of ARIZONA STATE UNIVERSITY
- 当前专利权人地址： Tempe, AZ 85287 US
- 代理机构： Didmon, Mark
- 优先权： US200395P 20000427
- 国际公布： WO2001081355 20011101
- 主分类号： C07F9/02
- IPC分类号： C07F9/02 ; C07F9/22 ; C07F9/28 ; A01N57/00 ; A01N57/26 ; A61K31/66 ; A61K31/685
摘要：
The present invention relates to the syntheses and structural elucidation of Combretastatin A1-Phosphate Prodrugs and Combretastatin B1-Phosphate Prodrugs and the utilization of those prodrugs in the treatment of neoplastic diseases. The prodrugs described herein have the structure: Combretastin A-1 Phosphate Prodrug (I) and Combretastin B-1 Phosphate Prodrug (II).
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