发明公开
- 专利标题： SOLUBLE BETA AMYLOID PRECURSOR PROTEIN SECRETION PROMOTERS
- 专利标题（中）： 可溶性β淀粉样前体蛋白分泌促进剂
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申请号： EP01919795.3申请日： 2001-04-05
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公开(公告)号： EP1283055A1公开(公告)日： 2003-02-12
- 发明人: KAKIHANA, Mitsuru , KATO, Kaneyoshi , MORI, Masaaki , YAMASHITA, Toshiro
- 申请人： Takeda Chemical Industries, Ltd.
- 申请人地址： 1-1 Doshomachi 4-chome, Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人地址： 1-1 Doshomachi 4-chome, Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 代理机构： Lewin, John Harvey
- 优先权： JP2000111912 20000407
- 国际公布： WO01076629 20011018
- 主分类号： A61K45/00
- IPC分类号： A61K45/00 ; A61K31/4706 ; A61K31/4709 ; C07D215/42 ; C07D215/44 ; C07D401/12 ; C07D405/12 ; C07D409/12 ; C07D413/12 ; A61P43/00 ; A61P25/00 ; A61P25/28 ; A61P25/16
摘要：
According to the present invention, there are provided compounds represented by formula (I):
[wherein R 1 and R 2 represent hydrogen atom, a lower alkyl group, etc.; ring A is an optionally substituted benzene ring, X is oxygen atom, etc.; and Y represents CH or N] or salts thereof, or prodrugs thereof, and use thereof as well as processes of manufacturing these compounds. The compounds of the present invention and the like possess a potent soluble beta amyloid precursor protein secretion promoting activity and suppress the functional disorders or apoptosis of cells, in particular neurons, mediated by the secreted soluble beta amyloid precursor proteins having a neurotrophic factor like property.
[wherein R 1 and R 2 represent hydrogen atom, a lower alkyl group, etc.; ring A is an optionally substituted benzene ring, X is oxygen atom, etc.; and Y represents CH or N] or salts thereof, or prodrugs thereof, and use thereof as well as processes of manufacturing these compounds. The compounds of the present invention and the like possess a potent soluble beta amyloid precursor protein secretion promoting activity and suppress the functional disorders or apoptosis of cells, in particular neurons, mediated by the secreted soluble beta amyloid precursor proteins having a neurotrophic factor like property.
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