- 专利标题: T CELL RECEPTOR FUSIONS AND CONJUGATES AND METHODS OF USE THEREOF
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申请号: EP01941935.7申请日: 2001-06-05
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公开(公告)号: EP1289564B1公开(公告)日: 2018-07-18
- 发明人: WEIDANZ, Jon, A. , CARD, Kimberlyn, F. , WONG, Hing, C.
- 申请人: Altor BioScience Corporation
- 申请人地址: 2810 North Commerce Parkway Miramar, Florida 33025 US
- 专利权人: Altor BioScience Corporation
- 当前专利权人: Altor BioScience Corporation
- 当前专利权人地址: 2810 North Commerce Parkway Miramar, Florida 33025 US
- 代理机构: Hiebl, Inge Elisabeth
- 优先权: US209536P 20000605
- 国际公布: WO2001093913 20011213
- 主分类号: A61K47/66
- IPC分类号: A61K47/66
摘要:
Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured are methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.
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