发明授权
- 专利标题: DERIVES DE PODOPHYLLOTOXINE CARBAMATE ET THIOCARBAMATE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
- 专利标题(英): Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them
- 专利标题(中): 衍生物和鬼臼毒素的硫代氨基甲酸酯,及其制造方法和药物组合物含
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申请号: EP01947525.0申请日: 2001-06-19
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公开(公告)号: EP1292597B1公开(公告)日: 2004-03-17
- 发明人: MONNERET, Claude , BERTOUNESQUE, Emmanuel , MERESSE, Philippe , ATASSI, Ghanem , PIERRE, Alain , HICKMAN, John , PFEIFFER, Bruno , RENARD, Pierre
- 申请人: Les Laboratoires Servier
- 申请人地址: 1, rue Carle Hébert 92415 Courbevoie Cedex FR
- 专利权人: Les Laboratoires Servier
- 当前专利权人: Les Laboratoires Servier
- 当前专利权人地址: 1, rue Carle Hébert 92415 Courbevoie Cedex FR
- 优先权: FR0007823 20000620
- 国际公布: WO2001098307 20011227
- 主分类号: C07D493/04
- IPC分类号: C07D493/04 ; A61K31/365 ; A61P35/00
摘要:
A compound selected from these of formula (I):wherein:R1 represents hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl or phosphono,R2 represents oxygen or sulphur,R3 represents hydrogen or alkyl, cycloalkyl or arylalkyl,X represents linear or branched (C1-C6)alkylene,R4 represents a group selected from amino optionally substituted by one or two groups, -N(R3)-X1-OR5 wherein R3, X1 and R5 are as defined in the description, -N(R3)-X1-NR6R7 wherein R3, X1, R6 and R7 are as defined in the description, hydroxy, alkoxy, aryloxy, -O-X1-OR5 wherein R5 and X1 are as defined in the description, and -O-X1-NR6R7 wherein R6, R7 and X1 are as defined in the description,its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base, and medical products containing the same which are useful in the treatment of cancer.
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