发明公开
EP1294918A2 REPLICATION DEFICIENT ADENOVIRAL TNF VECTOR
有权
REPLIKATIONSDEFIZIENTER ADENOVIRALER TNF VEKTOR
- 专利标题： REPLICATION DEFICIENT ADENOVIRAL TNF VECTOR
- 专利标题（中）： REPLIKATIONSDEFIZIENTER ADENOVIRALER TNF VEKTOR
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申请号： EP01950575.9申请日： 2001-06-27
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公开(公告)号： EP1294918A2公开(公告)日： 2003-03-26
- 发明人: BROUGH, Douglas, E. , KING, C., Richter , KOVESDI, Imre
- 申请人： GENVEC, INC.
- 申请人地址： 65 West Watkins Mill Road Gaithersburg,Maryland 20878 US
- 专利权人： GENVEC, INC.
- 当前专利权人： GENVEC, INC.
- 当前专利权人地址： 65 West Watkins Mill Road Gaithersburg,Maryland 20878 US
- 代理机构： Wössner, Gottfried, Dr. Dipl.-Chem.
- 优先权： US604694 20000627
- 国际公布： WO02000906 20020103
- 主分类号： C12N15/861
- IPC分类号： C12N15/861 ; C12N15/28 ; C07K14/525 ; C12N5/10 ; C12N7/01 ; A61K48/00
摘要：
An adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a radiation inducible promoter operably linked to the nucleic acid sequence coding for TNF. This invention also provides an adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a spacer element of at least 15 base pairs in the E4 region of the adenoviral genome. A method of producing an adenoviral vector and a method of treating a tumor or cancer in a host comprising administering an anti-cancer or anti-tumor effective amount of the adenoviral vector of the present invention also is provided.
公开/授权文献
- EP1294918B1 REPLICATION DEFICIENT ADENOVIRAL TNF VECTOR 公开/授权日：2005-10-12
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