发明授权
EP1309569B1 N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamide derivatives as PDGFRs inhibitors
有权
N-芳基 - {4- [7-（烷氧基）喹唑啉-4-基]哌嗪基}甲酰胺化合物作为PDGF受体阻断剂
- 专利标题： N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamide derivatives as PDGFRs inhibitors
- 专利标题（中）： N-芳基 - {4- [7-（烷氧基）喹唑啉-4-基]哌嗪基}甲酰胺化合物作为PDGF受体阻断剂
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申请号： EP01973654.5申请日： 2001-08-17
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公开(公告)号： EP1309569B1公开(公告)日： 2010-10-06
- 发明人: PANDEY, Anjali , SCARBOROUGH, Robert, M. , MATSUNO, Kenji , ICHIMURA, Michio , NOMOTO, Yuji , IDE, Shinichi , TSUKUDA, Eiji , IRIE, Junko , ODA, Shoji
- 申请人： MILLENNIUM PHARMACEUTICALS, INC. , Kyowa Hakko Kirin Co., Ltd.
- 申请人地址： 256 East Grand Avenue South San Francisco, California 94080 US
- 专利权人： MILLENNIUM PHARMACEUTICALS, INC.,Kyowa Hakko Kirin Co., Ltd.
- 当前专利权人： MILLENNIUM PHARMACEUTICALS, INC.,Kyowa Hakko Kirin Co., Ltd.
- 当前专利权人地址： 256 East Grand Avenue South San Francisco, California 94080 US
- 代理机构： Wombwell, Francis
- 优先权： US226089P 20000818
- 国际公布： WO2002016362 20020228
- 主分类号： C07D239/94
- IPC分类号： C07D239/94 ; C07D401/12 ; C07D403/12 ; A61K31/517 ; A61P35/00
摘要：
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
公开/授权文献
- EP1309569A2 NITROGENOUS HETEROCYCLIC COMPOUNDS 公开/授权日：2003-05-14
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