发明公开
EP1315516A2 MODULATION OF BETA-AMYLOID LEVELS BY BETA-SECRETASE BACE2
审中-公开
MODULIERUNG DES BETA-AMYLOID NIVEAUS DURCH BETA-SECRETASE BACE2
- 专利标题： MODULATION OF BETA-AMYLOID LEVELS BY BETA-SECRETASE BACE2
- 专利标题（中）： MODULIERUNG DES BETA-AMYLOID NIVEAUS DURCH BETA-SECRETASE BACE2
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申请号： EP01948768.5申请日： 2001-06-27
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公开(公告)号： EP1315516A2公开(公告)日： 2003-06-04
- 发明人: CORDELL, Barbara , SCHIMMOLLER, Frauke , LIU, Yu-Wang , QUON, Diana, Hom
- 申请人： Scios Inc.
- 申请人地址： 749 North Mary Avenue Sunnyvale, CA 94086 US
- 专利权人： Scios Inc.
- 当前专利权人： Scios Inc.
- 当前专利权人地址： 749 North Mary Avenue Sunnyvale, CA 94086 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US215729P 20000628
- 国际公布： WO02000913 20020103
- 主分类号： A61K38/48
- IPC分类号： A61K38/48 ; G01N33/50 ; A61P25/28
摘要：
The present invention is based on the findings that BACE2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of Aβ. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress Aβ production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases.
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