发明公开
EP1315739A2 PROCEDE DE COUPLAGE, EN SOLUTION, ENTRE UN PEPTIDE ET UN VECTEUR LIPOPHILE ET SES APPLICATIONS
有权
PROCESS FOR IN之间的肽和亲脂性化合物溶液的离合器，及其用途
- 专利标题： PROCEDE DE COUPLAGE, EN SOLUTION, ENTRE UN PEPTIDE ET UN VECTEUR LIPOPHILE ET SES APPLICATIONS
- 专利标题（英）： Method for binding, in solution, a peptide and a lipophilic vector and uses thereof
- 专利标题（中）： PROCESS FOR IN之间的肽和亲脂性化合物溶液的离合器，及其用途
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申请号： EP01967454.8申请日： 2001-09-07
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公开(公告)号： EP1315739A2公开(公告)日： 2003-06-04
- 发明人: BONNET, Dominique , BOUREL, Line , MELNYK, Oleg
- 申请人： INSTITUT PASTEUR DE LILLEEtablissement Public , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)
- 申请人地址： 1, rue du Professeur Calmette 59019 Lille Cédex FR
- 专利权人： INSTITUT PASTEUR DE LILLEEtablissement Public,CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)
- 当前专利权人： INSTITUT PASTEUR DE LILLEEtablissement Public,CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)
- 当前专利权人地址： 1, rue du Professeur Calmette 59019 Lille Cédex FR
- 代理机构： Lepeudry-Gautherat, Thérèse
- 优先权： FR0011451 20000908
- 国际公布： WO02020558 20020314
- 主分类号： C07K1/107
- IPC分类号： C07K1/107 ; A61K47/48 ; C07C233/03 ; C07D209/32 ; A61K39/395
摘要：
The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, said coupling comprising a step which consists in producing a hydrazone bond between said peptide compound and said lipophilic vector. The invention also concerns lipophilic vectors for use in said method, lipopeptides obtained by said method, uses of said lipopeptides for cell screening, and the applications of the invention, in particular for preparing targeting of an active principle of the peptide kind (for example hormone or neuropeptide) through physiological barriers such as cell membranes.
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