发明授权
- 专利标题： PROCEDE DE PROPAGATION, IN VITRO, DE L'AGENT RESPONSABLE DES ENCEPHALOPATHIES SPONGIFORMES TRANSMISSIBLES
- 专利标题（英）： Method for in vitro propagation of the agent responsible for transmissible spongiform encephalopathies
- 专利标题（中）： 程序的体外繁殖剂传染性海绵状脑病
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申请号： EP01972175.2申请日： 2001-09-20
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公开(公告)号： EP1319063B1公开(公告)日： 2007-07-18
- 发明人: BLANQUET GROSSARD, Françoise , CESBRON, Jean-Yves , LEMAIRE VIEILLE, Catherine , FOLLET, Jérôme
- 申请人： UNIVERSITE JOSEPH FOURIER (GRENOBLE 1)
- 申请人地址： Domaine Universitaire 38040 Saint Martin d'Heres FR
- 专利权人： UNIVERSITE JOSEPH FOURIER (GRENOBLE 1)
- 当前专利权人： UNIVERSITE JOSEPH FOURIER (GRENOBLE 1)
- 当前专利权人地址： Domaine Universitaire 38040 Saint Martin d'Heres FR
- 代理机构： Guerre, Dominique
- 优先权： FR0011989 20000920
- 国际公布： WO2002024871 20020328
- 主分类号： C12N5/06
- IPC分类号： C12N5/06 ; C12N1/04 ; C12P21/00 ; C12Q1/02
摘要：
The invention concerns a method for in vitro propagation of the agent responsible for transmissible spongiform encephalopathies, or prion, comprising steps which consist in: providing a culture or a glial cell line and in infecting the culture or line with the agent responsible for transmissible spongiform encephalopathies or prion. Said method enables to obtain infected cell lines capable of being used to assess the efficacy of a molecule in the reduction or inhibition of the infectiosity of the prion or for detecting the prion.
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