发明公开
- 专利标题： METHODS AND COMPOSITIONS FOR REGULATING MEMORY CONSOLIDATION
- 专利标题（中）： 方法和组合物用于调节记忆的巩固
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申请号： EP01924598.4申请日： 2001-04-02
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公开(公告)号： EP1331930A2公开(公告)日： 2003-08-06
- 发明人: ALBERINI, Cristina, M. , BEAR, Mark, F.
- 申请人： BROWN UNIVERSITY RESEARCH FOUNDATION , Howard Hughes Medical Institute
- 申请人地址： 42 Charlesfield Street Providence, RI 02912 US
- 专利权人： BROWN UNIVERSITY RESEARCH FOUNDATION,Howard Hughes Medical Institute
- 当前专利权人： BROWN UNIVERSITY RESEARCH FOUNDATION,Howard Hughes Medical Institute
- 当前专利权人地址： 42 Charlesfield Street Providence, RI 02912 US
- 代理机构： Chapman, Paul Gilmour
- 优先权： US193614P 20000331
- 国际公布： WO01074298 20011011
- 主分类号： A61K31/00
- IPC分类号： A61K31/00 ; A61K33/00 ; A61K38/00 ; A61K39/00
摘要：
The present invention is based on discovery of genes that are up- or down-regulated in inhibitory avoidance, e.g., long-term memory, which genes are therefor believed to have roles in memory consolidation. In particular, we have discovered that memory consolidation involves the regulation of expression of such genes as zif268 (EGR1), insulin-like growth factor (IGF-1), glutamate receptor (1 (GluR1), glutamate receptor 2 (GluR2), c/EBPβ and VGF. For ease of reading, these genes are collectively referred to herein as 'LTM genes', and their encoded proteins as 'LTM proteins'.
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