发明公开
EP1333831A2 AZA-AND POLYAZA-NAPHTHALENYL KETONES USEFUL AS HIV INTEGRASE INHIBITORS
审中-公开
用于HIV整合酶抑制剂的AZA-和POLYAZA-NAPHTHALENYL酮
- 专利标题： AZA-AND POLYAZA-NAPHTHALENYL KETONES USEFUL AS HIV INTEGRASE INHIBITORS
- 专利标题（中）： 用于HIV整合酶抑制剂的AZA-和POLYAZA-NAPHTHALENYL酮
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申请号： EP01990637.9申请日： 2001-10-09
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公开(公告)号： EP1333831A2公开(公告)日： 2003-08-13
- 发明人: ZHUANG, Linghang , WAI, John, S. , PAYNE, Linda, S. , YOUNG, Steven, D. , FISHER, Thorsten, E. , EMBREY, Mark , GUARE, James, P.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway,New Jersey 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway,New Jersey 07065-0907 US
- 代理机构： Horgan, James Michael Frederic
- 优先权： US239732P 20001012
- 国际公布： WO02036734 20020510
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61K31/495 ; C07D215/26 ; C07D471/04
摘要：
Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment or the delay in the onset of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.
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