发明公开
EP1339719A1 DERIVES DE BENZIMIDAZOLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
有权
DEIV苯并咪唑，LEUR制剂和LEUR应用EN THERAPEUQUE
- 专利标题： DERIVES DE BENZIMIDAZOLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
- 专利标题（英）： Benzimidazole derivatives, preparation and therapeutic use thereof
- 专利标题（中）： DEIV苯并咪唑，LEUR制剂和LEUR应用EN THERAPEUQUE
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申请号： EP01997491.4申请日： 2001-11-21
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公开(公告)号： EP1339719A1公开(公告)日： 2003-09-03
- 发明人: BARTH, Francis , BICHON, Daniel , BOLKENIUS, Frank , VAN DORSSELAER, Viviane
- 申请人： SANOFI-SYNTHELABO
- 申请人地址： 174, Avenue de France 75013 Paris FR
- 专利权人： SANOFI-SYNTHELABO
- 当前专利权人： SANOFI-SYNTHELABO
- 当前专利权人地址： 174, Avenue de France 75013 Paris FR
- 代理机构： Thouret-Lemaitre, Elisabeth
- 优先权： FR0015141 20001123; FR0106157 20010510
- 国际公布： WO02042306 20020530
- 主分类号： C07D487/06
- IPC分类号： C07D487/06 ; A61K31/5517 ; A61P9/00 ; A61P25/00 ; A61P29/00
摘要：
The invention concerns benzimidazole derivatives of general formula (I), wherein: X represents a nitrogen atom or a carbon atom; when X represents a nitrogen atom, R3 represents in particular a hydrogen atom or a C1-C4 alkyl group; R4 represents in particular a hydrogen atom, a C1-C6 alkyl, C3-C7 cycloalkyl, 4-piperidyl, -(CH2)p-NR5R6, -(CH2)p-CONR5R6, -CO-(CH2)p-NR5R6, -(CH2)p-phenyl, -(CH2)p-morpholinyl, -(CH2)p-pyrrolidinyl, -(CH2)p-tetrahydro-isoquinoline, -(CH2)p-heteoraryl, heteroarylcarbonyl, phenylcarbonyl, C1-C6 alkylcarbonyl, -(-CH2)p-COOR', or phenylsulphonyl group; and when X represents a carbon atom, R3 represents a hydrogen atom, a -NR5R6, -NHCOR7, -CONHR5, -COR7, -NHCONH2, -OH or -CH2OH; R4 represents in particular a hydrogen atom, a -(CH2)p-phenyl group optionally substituted, a -(CH2)p-heteroaryl or a (CH2)tNR7R8 group. The compounds of formula (I) of the invention can be used for preparing a medicine for treating or preventing disorders wherein the PARP enzyme is involved.
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