A radio network controller (RNC) transmits a power offset for controlling transmission power of an uplink high speed dedicated physical control channel (HS-DPCCH) when a user equipment (UE) enters a handover region, in a mobile communication system including the RNC, a Node B connected to the RNC, and the UE located in one of at least two cell areas occupied by the Node B. The Node B transmits data to the UE over a high speed downlink shared channel (HS-DSCH) and the UE transmits information indicating reception of the data to the Node B over the uplink HS-DPCCH. The RNC informs the UE of a power offset for determining a transmission power increment of the uplink HS-DPCCH, if it is determined that the UE is located in the handover region. The RNC informs the Node B of the power offset so that the Node B can determine a threshold value for determining information indicating reception of the data, depending on the power offset.