发明公开
EP1344781A1 Process for the depolymerization of glycosaminoglycanes and products obtained therefrom
审中-公开
Verfahren zur Depolymerisierung von Glykosaminoglykanen und so hergestellte Produkte
- 专利标题： Process for the depolymerization of glycosaminoglycanes and products obtained therefrom
- 专利标题（中）： Verfahren zur Depolymerisierung von Glykosaminoglykanen und so hergestellte Produkte
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申请号： EP02425142.3申请日： 2002-03-12
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公开(公告)号： EP1344781A1公开(公告)日： 2003-09-17
- 发明人: Gonella, Sergio , De Ambrosi, Luigi , Vismara, Elena
- 申请人： LABORATORI DERIVATI ORGANICI S.P.A.
- 申请人地址： Via M. Barozzi, 4 20122 Milano IT
- 专利权人： LABORATORI DERIVATI ORGANICI S.P.A.
- 当前专利权人： LABORATORI DERIVATI ORGANICI S.P.A.
- 当前专利权人地址： Via M. Barozzi, 4 20122 Milano IT
- 代理机构： Cleva, Maria Giovanna
- 主分类号： C08B37/08
- IPC分类号： C08B37/08 ; C08B37/10
摘要：
The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of high-energy radiation in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid.
The invention also relates to intermediate depolymerized heparin having Mw comprised between 1,000 and 5,500, absorbance at 400 nm below 0.300 and ratio SO 3 - /COO - equal to or higher than in the starting heparin.
The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by Gel Permeation for obtaining the desired Molecular Weight.
The invention also relates to intermediate depolymerized heparin having Mw comprised between 1,000 and 5,500, absorbance at 400 nm below 0.300 and ratio SO 3 - /COO - equal to or higher than in the starting heparin.
The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by Gel Permeation for obtaining the desired Molecular Weight.
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