发明公开
EP1355875A1 3,4-DI-SUBSTITUTED CYCLOBUTENE-1, 2-DIONES AS CXC CHEMOKINE RECEPTOR ANTAGONISTS
审中-公开
3,4-DISUBSTITUIERTE CYCLOBUTEN-1,2-DIONE ALS CXC CHEMOKIN-REZEPTOR-ANTAGONISTEN
- 专利标题： 3,4-DI-SUBSTITUTED CYCLOBUTENE-1, 2-DIONES AS CXC CHEMOKINE RECEPTOR ANTAGONISTS
- 专利标题（中）： 3,4-DISUBSTITUIERTE CYCLOBUTEN-1,2-DIONE ALS CXC CHEMOKIN-REZEPTOR-ANTAGONISTEN
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申请号： EP02731085.3申请日： 2002-02-01
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公开(公告)号： EP1355875A1公开(公告)日： 2003-10-29
- 发明人: TAVERAS, Arthur, G. , AKI, Cynthia, J., , BOND, Richard, W. , CHAO, Jianping , DWYER, Michael , FERREIRA, Johan, A. , PACHTER, Jonathan , BALDWIN, John, J. , KAISER, Bernd , LI, Ge , MERRITT, J., Robert , NELSON, Kingsley, H., Jr. , ROKOSZ, Laura, L.
- 申请人： SCHERING CORPORATION , PHARMACOPEIA, INC.
- 申请人地址： 2000 Galloping Hill Road Kenilworth,New Jersey 07033-0530 US
- 专利权人： SCHERING CORPORATION,PHARMACOPEIA, INC.
- 当前专利权人： SCHERING CORPORATION,PHARMACOPEIA, INC.
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth,New Jersey 07033-0530 US
- 代理机构： UEXKÜLL & STOLBERG
- 优先权： US265951P 20010202
- 国际公布： WO02076926 20021003
- 主分类号： C07C225/20
- IPC分类号： C07C225/20 ; C07C229/42 ; C07C229/64 ; C07C237/36 ; C07C237/44 ; C07C255/58 ; C07C255/59 ; C07C271/20 ; C07C311/08 ; C07C311/21 ; C07D205/04 ; C07D207/08 ; C07D207/16 ; C07D211/60 ; C07D213/89 ; C07D231/38 ; C07D235/06 ; C07D239/42 ; C07D249/18 ; C07D277/28 ; C07D285/08
摘要：
There are disclosed compounds of formula (I) wherein the variables A and B are an aryl or heteroaryl group as defined in the claims, or a prodrug thereof, or a pharmaceutically acceptable salt, solvate or isomer of said compound or of said prodrug, which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
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