发明授权
- 专利标题： METHODS OF MODIFYING EUKARYOTIC CELLS
- 专利标题（中）： 方法进行修饰真核细胞
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申请号： EP02709544.7申请日： 2002-02-15
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公开(公告)号： EP1360287B1公开(公告)日： 2012-09-12
- 发明人: MURPHY, Andrew, J. , YANCOPOULOS, George, D.
- 申请人： REGENERON PHARMACEUTICALS, INC.
- 申请人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591-6707 US
- 专利权人： REGENERON PHARMACEUTICALS, INC.
- 当前专利权人： REGENERON PHARMACEUTICALS, INC.
- 当前专利权人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591-6707 US
- 代理机构： Bentham, Andrew
- 优先权： US784859 20010216
- 国际公布： WO2002066630 20020829
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; C12N15/09 ; C12N15/63 ; C12N15/74
摘要：
A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.
公开/授权文献
- EP1360287B2 METHODS OF MODIFYING EUKARYOTIC CELLS 公开/授权日：2019-04-03
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