发明公开
- 专利标题: ANTAGONISTS OF MCP-1 FUNCTION AND METHODS OF USE THEREOF
- 专利标题(中): 的MCP-1活性拮抗剂和方法的使用
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申请号: EP02709746.8申请日: 2002-02-28
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公开(公告)号: EP1363897A2公开(公告)日: 2003-11-26
- 发明人: LABORDE, Edgardo , ROBINSON, Louise , MENG, Fanying , PETERSON, Brian, T. , VILLAR, Hugo, O. , ANUSKIEWICZ, Steven, E. , ISHIWATA, Yoshiro , YOKOCHI, Shoji , MATSUMOTO, Yukiharu , KAKIGAMI, Takuji , INAGAKI, Hideaki , JOMORI, Takahito , MATSUSHIMA, Kouji
- 申请人: TELIK, INC. , Sanwa Kagaku Kenkyusho Co., Ltd.
- 申请人地址: 750 Gateway Boulevard South San Francisco, CA 94080 US
- 专利权人: TELIK, INC.,Sanwa Kagaku Kenkyusho Co., Ltd.
- 当前专利权人: TELIK, INC.,Sanwa Kagaku Kenkyusho Co., Ltd.
- 当前专利权人地址: 750 Gateway Boulevard South San Francisco, CA 94080 US
- 代理机构: Barz, Peter
- 优先权: US272792P 20010301
- 国际公布: WO02070509 20020912
- 主分类号: C07D319/18
- IPC分类号: C07D319/18 ; C07D405/12 ; C07D409/12 ; C07D407/12 ; C07D241/42 ; C07D417/12 ; C07D401/12 ; C07D265/36 ; C07D215/48 ; A61K31/357 ; A61P29/00
摘要:
The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifically, this invention relates to novel compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection. More specifically, the invention is related to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases.
公开/授权文献
- EP1363897B1 ANTAGONISTS OF MCP-1 FUNCTION AND METHODS OF USE THEREOF 公开/授权日:2005-12-21
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