发明公开
- 专利标题： MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS
- 专利标题（中）： 黑色素聚集激素END受体配体
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申请号： EP01957558.8申请日： 2001-07-06
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公开(公告)号： EP1366030A2公开(公告)日： 2003-12-03
- 发明人: BAKTHAVATCHALAM, Rajagopal , HUTCHISON, Alan , THURKAUF, Andrew
- 申请人： Neurogen Corporation
- 申请人地址： 23 Northeast Industrial Road Branford, CT 06405 US
- 专利权人： Neurogen Corporation
- 当前专利权人： Neurogen Corporation
- 当前专利权人地址： 23 Northeast Industrial Road Branford, CT 06405 US
- 代理机构： Eyles, Christopher Thomas
- 优先权： US216081P 20000706
- 国际公布： WO02004433 20020117
- 主分类号： C07D295/096
- IPC分类号： C07D295/096 ; A61K31/495 ; A61P3/04 ; C07D295/08 ; C07D295/06 ; C07D295/18 ; C07D211/22 ; A61K31/445
摘要：
Disclosed are compounds of formula (I), and the pharmaceutically acceptable salts thereof wheren Q, X, Y, Z, and R1 R9, and R12-R19 are defined herein. These compounds are selective modulators of MCH 1 receptors that are, therefore, useful in the treatment of a variety of metabolic, feeding, and sexual disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also disclosed.
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