发明公开
EP1370554A1 3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS
有权
3-（4- AMIDOPYRROL -2-基亚甲基）-2-二氢吲哚酮衍生物ALS蛋白激酶抑制剂
- 专利标题： 3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS
- 专利标题（中）： 3-（4- AMIDOPYRROL -2-基亚甲基）-2-二氢吲哚酮衍生物ALS蛋白激酶抑制剂
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申请号： EP02714897.2申请日： 2002-02-15
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公开(公告)号： EP1370554A1公开(公告)日： 2003-12-17
- 发明人: GUAN, Huiping , LIANG, Congxin , SUN, Li , TANG, Peng, Cho , WEI, Chung, Chen , MAURAGIS, Michael, A. , VOJKOVSKY, Tomas , JIN, Qingwu , HERRINTON, Paul, Matthew
- 申请人： PHARMACIA & UPJOHN COMPANY , Sugen, Inc.
- 申请人地址： 301 Henrietta Street Kalamazoo,Michigan 49001 US
- 专利权人： PHARMACIA & UPJOHN COMPANY,Sugen, Inc.
- 当前专利权人： PHARMACIA & UPJOHN COMPANY,Sugen, Inc.
- 当前专利权人地址： 301 Henrietta Street Kalamazoo,Michigan 49001 US
- 代理机构： Harrison Goddard Foote
- 优先权： US268683P 20010215; US312361P 20010815
- 国际公布： WO02066463 20020829
- 主分类号： C07D403/06
- IPC分类号： C07D403/06 ; C07D403/14 ; C07D471/04 ; A61K31/404 ; A61K31/4166 ; A61K31/437 ; A61K31/5377 ; A61K31/541 ; A61P35/00
摘要：
The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
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