发明公开
- 专利标题: NOVEL HETEROCYCLIC DERIVATIVES
- 专利标题(中): 杂环化合物
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申请号: EP02722787.5申请日: 2002-04-25
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公开(公告)号: EP1382598A1公开(公告)日: 2004-01-21
- 发明人: KAKIHANA, Mitsuru , KATO, Kaneyoshi , MORI, Masaaki , YAMASHITA, Toshiro
- 申请人: Takeda Chemical Industries, Ltd.
- 申请人地址: 1-1 Doshomachi 4-chome, Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人地址: 1-1 Doshomachi 4-chome, Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 代理机构: Rickard, Timothy Mark Adrian
- 优先权: JP2001128677 20010426; JP2002043523 20020220
- 国际公布: WO2002088087 20021107
- 主分类号: C07D215/44
- IPC分类号: C07D215/44 ; C07D401/04 ; C07D471/10 ; C07D413/04 ; C07D401/14 ; C07D417/04 ; C07D417/14 ; C07D409/14 ; C07D405/14 ; A61K31/4709 ; A61K31/538 ; A61K31/5415 ; A61K31/498 ; A61K31/55 ; A61K31/473 ; A61K31/4725 ; A61K31/496 ; A61P25/00 ; A61P25/16 ; A61P25/28 ; A61P43/00
摘要:
The object of the present invention is to provide soluble β-amyloid precursor protein secretory stimulators, which are effective in treating neurodegenerative diseases as well as cerebrovascular disorder-induced neuronopathy. More specifically, the present invention provides a novel compound of the following Formula (I) or a salt or prodrug thereof:
[wherein R 1 and R 2 each represent a hydrogen atom or a lower alkyl group, etc., Ar 1 and the ring B each represent an optionally substituted aromatic group, the ring A represents an optionally substituted benzene ring, the ring C represents an optionally substituted 4- to 8-membered ring which may further be condensed with an optionally substituted ring, X represents CH or N, and Y represents CH or N].
[wherein R 1 and R 2 each represent a hydrogen atom or a lower alkyl group, etc., Ar 1 and the ring B each represent an optionally substituted aromatic group, the ring A represents an optionally substituted benzene ring, the ring C represents an optionally substituted 4- to 8-membered ring which may further be condensed with an optionally substituted ring, X represents CH or N, and Y represents CH or N].
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