发明授权
- 专利标题: N-AROYL CYCLIC AMINES
- 专利标题(中): 的N-芳酰基环胺
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申请号: EP02722482.3申请日: 2002-05-02
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公开(公告)号: EP1385845B1公开(公告)日: 2008-01-09
- 发明人: BRANCH, Clive, Leslie, c/o GlaxoSmithKline , COULTON, Steven, c/o GlaxoSmithKline , JOHNS, Amanda, c/o GlaxoSmithKline , JOHNSON, Christopher, Norbert, c/o GlaxoSmithKlin , PORTER, Roderick, Alan, c/o GlaxoSmithKline , STEMP, Geoffrey, c/o GlaxoSmithKline , THEWLIS, Kevin, c/o GlaxoSmithKline
- 申请人: SMITHKLINE BEECHAM PLC
- 申请人地址: 980 Great West Road Brentford, Middlesex TW8 9GS GB
- 专利权人: SMITHKLINE BEECHAM PLC
- 当前专利权人: SMITHKLINE BEECHAM PLC
- 当前专利权人地址: 980 Great West Road Brentford, Middlesex TW8 9GS GB
- 代理机构: Lawrence, Geoffrey Mark Prouse
- 优先权: GB0111189 20010505; GB0111184 20010505; GB0121303 20010903; GB0130392 20011219; GB0130331 20011219
- 国际公布: WO2002090355 20021114
- 主分类号: C07D417/14
- IPC分类号: C07D417/14 ; A61K31/445 ; C07D413/12 ; C07D413/14 ; C07D401/12 ; A61K31/505 ; C07D471/04 ; A61K31/5377 ; C07D401/14 ; C07D498/04 ; C07D403/14 ; A61P25/20 ; A61P9/10 ; A61P3/04
摘要:
This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3; m represents 1, 2, or 3; p represents O or 1; X is NR, wherein R is H or (C1-4)alkyl; Ar1 is aryl, or a mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S; any of which may be optionally substituted; A2 represents phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S, wherein the phenyl or heterocyclyl group is substituted by R1 and further optional substituents; or Ar2 represents an optionally substituted bicyclic aromatic or bicyclic heteroaromatic group containing up to 3 heteroatoms selected from N, O and S; R1 represents hydrogen, optionally substituted (C¿1-4?)alkoxy, halo, cyano, optionally substituted (C1-6)alkyl, optionally substituted phenyl, or an optionally substituted 5- or 6- membered heterocyclyl group containing up to 4 heteroatoms selected from N, O and S; when Ar?1¿ is aryl p is not 1; or a pharmaceutical acceptable salt thereof.
公开/授权文献
- EP1385845A1 N-AROYL CYCLIC AMINES 公开/授权日:2004-02-04
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