发明公开
EP1389460A1 CXCR4-ANTAGONISTIC DRUGS COMPRISING NITROGEN-CONTAINING COMPOUND
审中-公开
CXCR4-ANTAGONISTISCHE ARZNEIMITTEL MIT EINER STICKSTOFFHALTIGEN VERBINDUNG
- 专利标题： CXCR4-ANTAGONISTIC DRUGS COMPRISING NITROGEN-CONTAINING COMPOUND
- 专利标题（中）： CXCR4-ANTAGONISTISCHE ARZNEIMITTEL MIT EINER STICKSTOFFHALTIGEN VERBINDUNG
-
申请号： EP02771732.1申请日： 2002-05-20
-
公开(公告)号： EP1389460A1公开(公告)日： 2004-02-18
- 发明人: YANAKA, Mikiro , YAMAZAKI, Toru , BANNAI, Kenji , HIROSE, Kunitaka
- 申请人： Kureha Chemical Industry Co., Ltd.
- 申请人地址： 1-9-11, Nihonbashihoridome-cho, Chuo-ku Tokyo 103-8552 JP
- 专利权人： Kureha Chemical Industry Co., Ltd.
- 当前专利权人： Kureha Chemical Industry Co., Ltd.
- 当前专利权人地址： 1-9-11, Nihonbashihoridome-cho, Chuo-ku Tokyo 103-8552 JP
- 代理机构： Forstmeyer, Dietmar, Dr. rer. nat., Dipl.-Chem.
- 优先权： JP2001154904 20010524
- 国际公布： WO2002094261 20021128
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/4164 ; A61K31/4178 ; A61K31/4402 ; A61K31/4439 ; A61K31/444 ; A61K31/4709 ; A61K31/506 ; A61P29/00 ; A61P35/04 ; A61P43/00 ; C07D207/337 ; C07D213/36 ; C07D215/40 ; C07D233/64 ; C07D233/88 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D409/14
摘要：
To provide novel nitrogen-containing compounds having antagonism to CXCR4 and remedies for disease, such as rheumatism, cancer metastasis, etc., based on the CXCR4 antagonism.
Nitrogen-containing compounds represented by the following general formula and CXCR4 antagonists containing these compounds as an active ingredient can be provided.
The above compounds are typified by nitrogen-containing compounds represented by the following general formula (I)
wherein A 1 and A 2 represent each a guanidino group or a group represented by the following general formula (ia)
(wherein A 3 represents a monocyclic or polycyclic heterocyclic aromatic ring group having 1 or 2 hetero atoms; B 1 represents a single bond or alkylene group; and R 1 represents hydrogen or alkyl group; W represents alkylene group having 2 to 3 carbon atoms, cyclic alkylene group having 5 to 10 carbon atoms, aromatic ring having 6 to 10 carbon atoms or heterocyclic aromatic ring having 5 to 10 carbon atoms; y is - (C=O) -; x is -C (=O) -NH-; n 1 is an integer of 1 or 2; n 2 is an integer of 2 or 3; and D is selected from among various substituents:
Nitrogen-containing compounds represented by the following general formula and CXCR4 antagonists containing these compounds as an active ingredient can be provided.
The above compounds are typified by nitrogen-containing compounds represented by the following general formula (I)
wherein A 1 and A 2 represent each a guanidino group or a group represented by the following general formula (ia)
(wherein A 3 represents a monocyclic or polycyclic heterocyclic aromatic ring group having 1 or 2 hetero atoms; B 1 represents a single bond or alkylene group; and R 1 represents hydrogen or alkyl group; W represents alkylene group having 2 to 3 carbon atoms, cyclic alkylene group having 5 to 10 carbon atoms, aromatic ring having 6 to 10 carbon atoms or heterocyclic aromatic ring having 5 to 10 carbon atoms; y is - (C=O) -; x is -C (=O) -NH-; n 1 is an integer of 1 or 2; n 2 is an integer of 2 or 3; and D is selected from among various substituents:
信息查询
