发明公开
EP1389623A2 Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin d analogs, and other compounds
失效
的24羟基化的中间体立体有择制备用于Aminosterin-和维生素D类似物和其它化合物的制备
- 专利标题： Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin d analogs, and other compounds
- 专利标题（中）： 的24羟基化的中间体立体有择制备用于Aminosterin-和维生素D类似物和其它化合物的制备
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申请号： EP03011093.6申请日： 1997-12-08
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公开(公告)号： EP1389623A2公开(公告)日： 2004-02-18
- 发明人: Kinney, William A. , Jones, Steven , Zhang, Xuehai , Rao, Meena N. , Bulliard, Michel , Meckler, Harold , Lee, Nancy
- 申请人： MAGAININ PHARMACEUTICALS INC.
- 申请人地址： 5110 Campus Drive Plymouth Meeting PA 19462 US
- 专利权人： MAGAININ PHARMACEUTICALS INC.
- 当前专利权人： MAGAININ PHARMACEUTICALS INC.
- 当前专利权人地址： 5110 Campus Drive Plymouth Meeting PA 19462 US
- 代理机构： Corizzi, Valérie
- 优先权： US32378P 19961206; US985876 19971205
- 主分类号： C07J41/00
- IPC分类号： C07J41/00 ; C07J9/00 ; C07J31/00
摘要：
A method is described for stereoselectively reducing an unsaturated alkyl ketone substituant attached to a fused ring base such as a steroid ring base or a Vitamin D3 analog ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent to stereoselectively reduce the unsaturated alkyl ketone to an unsaturated alkyl alcohol.
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