发明授权
EP1390488B1 CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE
有权
2-C-甲基-D-赤藓醇2,4-环二合酶的晶体结构
- 专利标题： CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE
- 专利标题（中）： 2-C-甲基-D-赤藓醇2,4-环二合酶的晶体结构
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申请号： EP02748701.6申请日： 2002-05-13
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公开(公告)号： EP1390488B1公开(公告)日： 2007-08-29
- 发明人: BACHER, Adelbert , HECHT, Stefan , HUBER, Robert , KAISER, Johannes , ROHDICH, Felix , STEINBACHER, Stefan
- 申请人： Bacher, Adelbert , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- 申请人地址： Königsbergerstrasse 74 85748 Garching DE
- 专利权人： Bacher, Adelbert,Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- 当前专利权人： Bacher, Adelbert,Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- 当前专利权人地址： Königsbergerstrasse 74 85748 Garching DE
- 代理机构： Hartz, Nikolai
- 优先权： DE10123597 20010515; US293875P 20010525
- 国际公布： WO2002092800 20021121
- 主分类号： C12N9/88
- IPC分类号： C12N9/88 ; G06F17/50 ; G06F19/00
摘要：
This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.
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