发明公开
EP1390751A2 DISPOSITIF DE PRESENTATION DE POLYPEPTIDES, UTILISABLE COMME "PUCE" POUR LA DETECTION MINIATURISEE DE MOLECULES.
有权
DEVICE FORPOLYPEPTIDPRÄSENTATION，用作传感器芯片检测分子的小型化
- 专利标题： DISPOSITIF DE PRESENTATION DE POLYPEPTIDES, UTILISABLE COMME "PUCE" POUR LA DETECTION MINIATURISEE DE MOLECULES.
- 专利标题（英）： Device for presenting polypeptides, able to be used as a chip for miniaturised detection of molecules
- 专利标题（中）： DEVICE FORPOLYPEPTIDPRÄSENTATION，用作传感器芯片检测分子的小型化
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申请号： EP02740818.6申请日： 2002-05-27
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公开(公告)号： EP1390751A2公开(公告)日： 2004-02-25
- 发明人: MELNYK, Oleg , GRAS-MASSE, Hélène , OLIVIER, Christophe , DURAND, Jean-Olivier , AURIAULT, Claude , DUBURCQ, Xavier , BOUZIDI, Ahmed , GARCIA, Jean-Michel , EL-MAHDI, Ouafâa
- 申请人： Societe d'Etude et de Developpement des Antigenes, Combinatoires - Sedac Therapeutics , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITE DE LILLE II
- 申请人地址： Parc Eurasanté,Le Galénis,Bâtiment B,85, rue Nelson Mandela 59120 Loos FR
- 专利权人： Societe d'Etude et de Developpement des Antigenes, Combinatoires - Sedac Therapeutics,CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS),INSTITUT PASTEUR DE LILLE,UNIVERSITE DE LILLE II
- 当前专利权人： Societe d'Etude et de Developpement des Antigenes, Combinatoires - Sedac Therapeutics,CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS),INSTITUT PASTEUR DE LILLE,UNIVERSITE DE LILLE II
- 当前专利权人地址： Parc Eurasanté,Le Galénis,Bâtiment B,85, rue Nelson Mandela 59120 Loos FR
- 代理机构： Lepeudry-Gautherat, Thérèse
- 优先权： FR0106931 20010528
- 国际公布： WO2002097442 20021205
- 主分类号： G01N33/543
- IPC分类号： G01N33/543 ; G01N33/68
摘要：
The invention relates to a device for presenting peptides or proteins which can be used as a polypeptide chip for miniaturized detection of molecules which structurally or functionally complement said polypeptides. Said device consists of a flat support where polypeptides are covalently bound. The link between the polypeptides and the support results from the formation of a semicarbazone link. The semicarbazone link is a specific result of the reaction between polypeptides having an aldehyde or ketone function; and a support functionalized by semicarbazide groupings. The invention also relates to a method for preparing the supports and attaching the polypeptides to these supports in addition to the use of said devices thus obtained as polypeptide chips .
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