发明公开
EP1397339A1 (ETHYLENE)-(PROPYLENE)-TRIAMINEPENTAACETIC ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS
审中-公开
（乙烯） - （丙烯）-TRIAMINOPENTAESSIGSÄURE衍生物，生产和使用在制造药用物质方法
- 专利标题： (ETHYLENE)-(PROPYLENE)-TRIAMINEPENTAACETIC ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS
- 专利标题（中）： （乙烯） - （丙烯）-TRIAMINOPENTAESSIGSÄURE衍生物，生产和使用在制造药用物质方法
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申请号： EP02747430.3申请日： 2002-06-24
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公开(公告)号： EP1397339A1公开(公告)日： 2004-03-17
- 发明人: LEHMANN, Lutz , NIEDBALLA, Ulrich , PLATZEK, Johannes , FRIEBE, Matthias , HILGER, Christoph, Stephan , MERBACH, André, E. , JAKAB TOTH, Eva , RULOFF, Robert , LAUS, Sabrina
- 申请人： Schering Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 代理机构： Teipel, Stephan, Dr.
- 优先权： US300479P 20010622; DE10133435 20010710; US305936P 20010717; EP01117355 20010718; US328108P 20011010; US335106P 20011023
- 国际公布： WO2003000647 20030103
- 主分类号： C07C229/16
- IPC分类号： C07C229/16 ; C07C337/06 ; C07C233/43 ; C07C331/28 ; C07C229/76 ; C07D207/452 ; A61K49/04 ; A61K49/08 ; A61K49/22 ; A61K51/04 ; A61K31/28 ; A61K47/48
摘要：
The invention relates to a novel class of ligands, complexes comprising such ligands and a metal ion, and adducts of these metal complexes and a macromolecule. Pharmaceutical compositions and methods of making and using the ligand-metal complexes are also described. The invention also relates to the use of macromolecular adducts for enhancement of diagnostic imaging. In particular, the invention relates to (ethylene)-(propylene)-triaminepentaacetic acid (EPTPA) derivatives, a process for their production, and their use for the production of pharmaceutical agents for NMR diagnosis or radiodiagnosis or radiotherapy.
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