发明公开
EP1404329A1 SUBSTITUTED 4-ARYL-3-(3-ARYL-1-OXO-2-PROPENYL)-2(1H)-QUINOLINONES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF
审中-公开
取代的4-芳基-3-（3-芳基-1-氧代-2-丙烯基）-2（1H）-quinolinones和类似物作为胱天蛋白酶的活化剂和细胞凋亡诱导剂及其用途
- 专利标题： SUBSTITUTED 4-ARYL-3-(3-ARYL-1-OXO-2-PROPENYL)-2(1H)-QUINOLINONES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF
- 专利标题（中）： 取代的4-芳基-3-（3-芳基-1-氧代-2-丙烯基）-2（1H）-quinolinones和类似物作为胱天蛋白酶的活化剂和细胞凋亡诱导剂及其用途
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申请号： EP02741817.7申请日： 2002-06-04
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公开(公告)号： EP1404329A1公开(公告)日： 2004-04-07
- 发明人: CAI, Sui, Xiong , ZHANG, Han-Zhong , DREWE, John , KASIBHATLA, Shailaja
- 申请人： Cytovia, Inc.
- 申请人地址： 6650 Nancy Ridge Drive San Diego, CA 92121 US
- 专利权人： Cytovia, Inc.
- 当前专利权人： Cytovia, Inc.
- 当前专利权人地址： 6650 Nancy Ridge Drive San Diego, CA 92121 US
- 代理机构： Ritter, Stephen David
- 优先权： US295007P 20010604
- 国际公布： WO2002098425 20021212
- 主分类号： A61K31/47
- IPC分类号： A61K31/47
摘要：
The present invention is directed to substituted 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1H)-quinolinones and analogs thereof, represented by the general Formula I: wherein ar1, Ar2, R1-R6 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of anormal cells occurs.
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