发明公开
EP1406666A2 ADENOVIRAL VECTORS WITH CELL TYPE SPECIFICITY FOR MESENCHYMAL CELLS
审中-公开
间充质干细胞的特定腺病毒载体
- 专利标题： ADENOVIRAL VECTORS WITH CELL TYPE SPECIFICITY FOR MESENCHYMAL CELLS
- 专利标题（中）： 间充质干细胞的特定腺病毒载体
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申请号： EP02746193.8申请日： 2002-07-05
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公开(公告)号： EP1406666A2公开(公告)日： 2004-04-14
- 发明人: HAVENGA, Menzo, Jans, Emco , BOUT, Abraham , VOGELS, Ronald
- 申请人： Crucell Holland B.V.
- 申请人地址： Archimedesweg 4 2333 CN Leiden NL
- 专利权人： Crucell Holland B.V.
- 当前专利权人： Crucell Holland B.V.
- 当前专利权人地址： Archimedesweg 4 2333 CN Leiden NL
- 代理机构： Klein, Bart
- 优先权： EP01202619 20010706; US303734P 20010707; US10645 20011113
- 国际公布： WO2003004661 20030116
- 主分类号： A61K48/00
- IPC分类号： A61K48/00
摘要：
The present invention provides novel methods and means for delivering a heterologous nucleic acid of interest to mesenchymal stem cells by providing recombinant adenoviral vectors provided with, or having a natural tropism for mesenchymal stem cells, typically in combination with a reduced tropism for other kinds of cells, in particular liver cells. The invention also provides mesenchymal stem cells provided with a heterologous nucleic acid through the use of a recombinant adenoviral vector according to the invention, and the use of such mesenchymal stem cells for the preparation of medicaments for the treatment of multiple sclerosis, rheumatoid arthritis, angiogenesis and bone related disorders, for instance in treatments that involve bone (re)generation.
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