发明公开
EP1409012A1 METHODS OF INDUCING A CYTOTOXIC IMMUNE RESPONSE AND RECOMBINANT SIMIAN ADENOVIRUS COMPOSITIONS USEFUL THEREIN
有权
PROCEDURE细胞毒免疫反应释放确保两有用的重组腺病毒APE组合物
- 专利标题： METHODS OF INDUCING A CYTOTOXIC IMMUNE RESPONSE AND RECOMBINANT SIMIAN ADENOVIRUS COMPOSITIONS USEFUL THEREIN
- 专利标题（中）： PROCEDURE细胞毒免疫反应释放确保两有用的重组腺病毒APE组合物
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申请号： EP02780874.0申请日： 2002-05-13
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公开(公告)号： EP1409012A1公开(公告)日： 2004-04-21
- 发明人: ERTL, Hildegund, C., J. , WILSON, James, M.
- 申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , The Trustees of The University of Pennsylvania
- 申请人地址： 3601 Spruce Street Philadelpia, PA 19104-4268 US
- 专利权人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY,The Trustees of The University of Pennsylvania
- 当前专利权人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY,The Trustees of The University of Pennsylvania
- 当前专利权人地址： 3601 Spruce Street Philadelpia, PA 19104-4268 US
- 代理机构： Hale, Stephen Geoffrey
- 优先权： US300131P 20010622; US304843P 20010712
- 国际公布： WO2003000283 20030103
- 主分类号： A61K39/295
- IPC分类号： A61K39/295
摘要：
A method of inducing a CD8+ T-cell response against a selected molecule by delivering the molecule via a recombinant simian adenovirus is provided. Also provided are methods of inducing interferon-alpha and interferon-beta by delivering a recombinant simian adenovirus to a subject. The methods of the invention are particularly well suited for prophylaxis and treatment of infections with human immunodeficiency virus and human papilloma virus, among others, and cancer therapy.
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