发明授权
EP1412331B1 PROCESS FOR THE PRODUCTION OF 4-AMINO-2,5-BISHETEROCYCLYLQUINAZOLINES 有权
生产4-氨基-2,5-二(新)苄基喹唑啉的方法

PROCESS FOR THE PRODUCTION OF 4-AMINO-2,5-BISHETEROCYCLYLQUINAZOLINES
摘要:
The invention provides a process for the production of a compound of formula (A), or a pharmaceutically acceptable salt or solvate thereof, wherein R1 represents C¿1-4? alkoxy optionally substituted by one or more fluorine atoms; R?2¿ represents H or C¿1-6? alkoxy optionally substituted by one or more fluorine atoms; R?3¿ represents a 5- or 6-membered heterocyclic ring which is optionally substituted; R4 is a 4-, 5-, 6- or 7-membered heterocyclic ring which is optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring, the ring system as a whole being optionally substituted; the process comprising condensing a compound of formula (B), wherein R1 to R3 are as defined above; with a compound of formula (C), wherein R?5 and R6¿ taken together with the N atom to which they are attached represent a 4-, 5-, 6-, or 7-membered N-containing heterocyclic ring, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring, the ring system as a whole being optionally substituted.
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