发明授权
EP1412331B1 PROCESS FOR THE PRODUCTION OF 4-AMINO-2,5-BISHETEROCYCLYLQUINAZOLINES
有权
生产4-氨基-2,5-二(新)苄基喹唑啉的方法
- 专利标题: PROCESS FOR THE PRODUCTION OF 4-AMINO-2,5-BISHETEROCYCLYLQUINAZOLINES
- 专利标题(中): 生产4-氨基-2,5-二(新)苄基喹唑啉的方法
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申请号: EP02745749.8申请日: 2002-07-19
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公开(公告)号: EP1412331B1公开(公告)日: 2006-04-19
- 发明人: BOULTON, Lee, Terence, c/o Pfizer Limited , CROOK, Robert, James, c/o Pfizer Global Res.& Dev. , PETTMAN, Alan, John, c/o Pfizer Global Res. & Dev. , WALTON, Robert, c/o Pfizer Global Res. & Dev.
- 申请人: Pfizer Limited , PFIZER INC.
- 申请人地址: Ramsgate Road Sandwich, Kent CT13 9NJ GB
- 专利权人: Pfizer Limited,PFIZER INC.
- 当前专利权人: Pfizer Limited,PFIZER INC.
- 当前专利权人地址: Ramsgate Road Sandwich, Kent CT13 9NJ GB
- 代理机构: Bridle, Andrew Barry
- 优先权: GB0118752 20010801
- 国际公布: WO2003011829 20030213
- 主分类号: C07D213/57
- IPC分类号: C07D213/57 ; C07D217/06 ; C07D401/14
摘要:
The invention provides a process for the production of a compound of formula (A), or a pharmaceutically acceptable salt or solvate thereof, wherein R1 represents C¿1-4? alkoxy optionally substituted by one or more fluorine atoms; R?2¿ represents H or C¿1-6? alkoxy optionally substituted by one or more fluorine atoms; R?3¿ represents a 5- or 6-membered heterocyclic ring which is optionally substituted; R4 is a 4-, 5-, 6- or 7-membered heterocyclic ring which is optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring, the ring system as a whole being optionally substituted; the process comprising condensing a compound of formula (B), wherein R1 to R3 are as defined above; with a compound of formula (C), wherein R?5 and R6¿ taken together with the N atom to which they are attached represent a 4-, 5-, 6-, or 7-membered N-containing heterocyclic ring, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring, the ring system as a whole being optionally substituted.
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