发明公开
EP1414450A1 (PYRIDINYL AND PYRIMIDYL)TRIENOIC ACID DERIVATIVES AS RETINOID X RECEPTOR MODULATORS
审中-公开
（吡啶基和嘧啶基）TRIE酸衍生物AS调节剂的类视黄醇X受体
- 专利标题： (PYRIDINYL AND PYRIMIDYL)TRIENOIC ACID DERIVATIVES AS RETINOID X RECEPTOR MODULATORS
- 专利标题（中）： （吡啶基和嘧啶基）TRIE酸衍生物AS调节剂的类视黄醇X受体
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申请号： EP02750182.4申请日： 2002-07-18
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公开(公告)号： EP1414450A1公开(公告)日： 2004-05-06
- 发明人: GRESE, Timothy, Alan , GARDINIER, Kevin, M. , BOEHM, Marcus, F.
- 申请人： ELI LILLY AND COMPANY , LIGAND PHARMACEUTICALS INCORPORATED
- 申请人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 专利权人： ELI LILLY AND COMPANY,LIGAND PHARMACEUTICALS INCORPORATED
- 当前专利权人： ELI LILLY AND COMPANY,LIGAND PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 代理机构： Gambell, Derek
- 优先权： US306951P 20010720
- 国际公布： WO2003007950 20030130
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/513 ; A61P3/10 ; C07D213/65 ; C07D239/34
摘要：
The present invention relates to a method of modulating retinoid X receptor activity in a mammal, novel compounds and pharmaceutical compositions for modulating retinoid X receptor activity in a mammal, and methods of making compounds that modulate retinoid X receptor activity in a mammal. The compounds are represented by Structural Formula I: The compounds of Structural Formula I are efficacious insulin sensitizers and do not have the undesirable side effects of increasing triglycerides or suppressing the thyroid hormone axis.
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