A dispenser bottle and associated closure has a sifter (22) disposed in the neck thereof, either in the form of castellated vents (24) formed in the interior peripheral edge of the neck or a separate sifter element. A rotatable cap (14) is positioned over the sifter. The cap has holes (16) that align with the vents or holes (24) in the sifter to dispense material from the bottle. A removable lock ring (18) is removeably conjoined to the cap to evidence tampering. One embodiment employs a squeeze tab (154a,b) that is depressed to open the bottle thereby increasing the dexterity required for opening. Another embodiment employs a rotatable sifter that must be held by one hand while the cap is held and rotated relative to the sifter by the other hand. A detent provides resistance to opening.