发明公开
EP1417205A1 ISOXAZOLYL-PYRIMIDINES AS INHIBITORS OF SRC AND LCK PROTEIN KINASES
有权
异恶唑，嘧啶，其SRC的抑制剂，LCK蛋白激酶
- 专利标题： ISOXAZOLYL-PYRIMIDINES AS INHIBITORS OF SRC AND LCK PROTEIN KINASES
- 专利标题（中）： 异恶唑，嘧啶，其SRC的抑制剂，LCK蛋白激酶
-
申请号： EP02744355.5申请日： 2002-06-14
-
公开(公告)号： EP1417205A1公开(公告)日： 2004-05-12
- 发明人: BEMIS, Guy , GAO, Huai , HARRINGTON, Edmund , LEDEBOER, Mark , SALITURO, Francesco , WANG, Jian
- 申请人： VERTEX PHARMACEUTICALS INCORPORATED
- 申请人地址： Patent Department,130 Waverly Street Cambridge, MA 02139-4242 US
- 专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： Patent Department,130 Waverly Street Cambridge, MA 02139-4242 US
- 代理机构： Cornish, Kristina Victoria Joy
- 优先权： US302969P 20010703
- 国际公布： WO2003004492 20030116
- 主分类号： C07D413/04
- IPC分类号： C07D413/04 ; A61K31/506 ; A61P35/02 ; A61P37/00
摘要：
The present invention provides compounds of formula I or a pharmaceutically acceptable derivative thereof, wherein A-B is N-O or O-N and G, R?1, R2, R3, and R4¿ are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of Src and Lck kinase. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
公开/授权文献
信息查询
