发明公开
- 专利标题: PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES
- 专利标题(中): 生物活性metallopeptides的肽模拟
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申请号: EP02768507.2申请日: 2002-08-12
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公开(公告)号: EP1425029A1公开(公告)日: 2004-06-09
- 发明人: SHARMA, Shubh, D. , SHI, Yiqun , RAJPUROHIT, Ramesh , WU, Zhijun
- 申请人: Palatin Technologies, Inc.
- 申请人地址: 103 Carnegie Center,Suite 200 Princeton, NJ 08540 US
- 专利权人: Palatin Technologies, Inc.
- 当前专利权人: Palatin Technologies, Inc.
- 当前专利权人地址: 103 Carnegie Center,Suite 200 Princeton, NJ 08540 US
- 代理机构: Van Breda, Jacobus
- 优先权: US311404P 20010810
- 国际公布: WO2003013571 20030220
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; G01N31/00 ; G01N33/53 ; G06F19/00 ; C07K1/00 ; C07K14/00 ; C07D207/00 ; C07D209/02 ; C07D241/04 ; C07D295/00 ; C07D487/02
摘要:
The invention relates to a method of deriving a peptidomimetic of a biologically active metallopeptide, wherein the peptidomimetic includes at least one non-peptide ring structure defining a template space superimposable on a corresponding defined template space of the metallopeptide, and where the peptidomimetic further includes at least two elements independently including an amino acid residu, amino acid side chain moiety or derivative thereof, the elements defining and occupying a similar descriptor space as corresponding elements of the metallopeptide. The invention further relates to peptidomimetics with a template space heterocyclic ring structure, including 5-,6 and 8-membered and 5-5 and 6-5 bicyclic fused ring structure melanocortin receptor-specific peptidomimetics.
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