发明公开
- 专利标题： RACEMIC TAMSULOSIN FREE BASE AND METHODS OF MAKING THE SAME
- 专利标题（中）： 坦索罗辛的外消旋体游离碱及其制造方法
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申请号： EP02768175.8申请日： 2002-10-17
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公开(公告)号： EP1444199A1公开(公告)日： 2004-08-11
- 发明人: HOORN, Hans, Jan , PETERS, Theodorus, Hendricus, Antonius , PIS, Jaroslav
- 申请人： Synthon B.V.
- 申请人地址： Microweg 22 6545 CM Nijmegen NL
- 专利权人： Synthon B.V.
- 当前专利权人： Synthon B.V.
- 当前专利权人地址： Microweg 22 6545 CM Nijmegen NL
- 代理机构： Duxbury, Stephen
- 优先权： US330817P 20011031; US208009 20020731
- 国际公布： WO2003037851 20030508
- 主分类号： C07C303/44
- IPC分类号： C07C303/44 ; C07C217/54 ; C07C311/39
摘要：
Racemic tamsulosin free base is obtained in solid form. The solid form can be formed by precipitating racemic tamsulosin free base from a solvent that comprises at least one of water or a lower alcohol. The crystalline free base exhibits polymorphism and two unique forms are identified. Novel intermediates are disclosed useful in the production of tamsulosin free base: a sulfonic acid salt of 2-(o-ethoxyphenoxy)ethylamine and (3-aminosulfonyl-4-methoxy)phenylacetone.
公开/授权文献
- EP1444199B1 RACEMIC TAMSULOSIN FREE BASE AND METHODS OF MAKING THE SAME 公开/授权日：2008-12-17
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