发明公开
- 专利标题: BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS
- 专利标题(中): 苯并噻唑作为腺苷受体配体
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申请号: EP02803360.3申请日: 2002-11-09
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公开(公告)号: EP1448196A1公开(公告)日: 2004-08-25
- 发明人: FLOHR, Alexander , JAKOB-ROETNE, Roland , NORCROSS, Roger, David , RIEMER, Claus
- 申请人: F. Hoffmann-La Roche AG
- 申请人地址: Grenzacherstrasse 124 4070 Basel CH
- 专利权人: F. Hoffmann-La Roche AG
- 当前专利权人: F. Hoffmann-La Roche AG
- 当前专利权人地址: Grenzacherstrasse 124 4070 Basel CH
- 代理机构: Poppe, Regina
- 优先权: EP01127313 20011119
- 国际公布: WO2003043634 20030530
- 主分类号: A61K31/4412
- IPC分类号: A61K31/4412 ; C07D417/12 ; A61P25/16 ; A61P25/28
摘要:
The present invention relates to compounds of the general formula (I): wherein R is phenyl, pyridin-2-yl, -C(O)-O-lower alkyl, -C(O)-lower alkyl, -C(O)-morpholinyl, -C(O)-NR'2,-(CH2)N-NR'2or -(CH2)N-O-lower alkyl and R' may be hydrogen or lower alkyl; and to pharmaceutically acceptable acid addition salts thereof. The compounds disclosed in this application have a good affinity to the A2A receptor and therefore they may be used in the control or prevention of illnesses based on the modulation of the adenosine system, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, neuroprotection, schizophrenia, anxiety, pain, respiration deficits, depression, drug addiction, such as amphetamine, cocaine, opioids, ethanol, nicotine, cannabinoids, or against asthma, allergic responses, hypoxia, ischaemia, seizure and substance abuse. Furthermore, compounds of the present invention may be useful as sedatives, muscle relaxants, antipsychotics, antiepileptics, anticonvulsants and cardiaprotective agents for disorders such as coronary artery disease and heart failure.
公开/授权文献
- EP1448196B1 BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS 公开/授权日:2005-10-12
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