发明公开
- 专利标题： METHOD OF RESOLVING AMLODIPINE RACEMATE
- 专利标题（中）： 解聚阿米地平杀鼠剂的方法
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申请号： EP02802193.9申请日： 2002-10-23
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公开(公告)号： EP1448527A1公开(公告)日： 2004-08-25
- 发明人: SENANAYAKE, Chris, H. , TANOURY, Gerald, J. , WILKINSON, Harold, S. , BAKALE, Roger, P. , ZLOTA, Andrei, A. , SARANTEAS, Kostas
- 申请人： Sepracor, Inc.
- 申请人地址： 84 waterford Drive Marlborough, MA 01752-7010 US
- 专利权人： Sepracor, Inc.
- 当前专利权人： Sepracor, Inc.
- 当前专利权人地址： 84 waterford Drive Marlborough, MA 01752-7010 US
- 代理机构： Chapman, Paul Gilmour
- 优先权： US346250P 20011024
- 国际公布： WO2003035623 20030501
- 主分类号： C07D211/90
- IPC分类号： C07D211/90
摘要：
The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipation with tartaric acid in the presence of a non-aqueous solvent, such as N,N'-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0.25:1.0 greater than 0.75:1.0.
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