发明公开
EP1450809A2 NUCLEOSIDES PREPARATION THEREOF AND USE AS INHIBITORS OF RNA VIRAL POLYMERASES
审中-公开
核苷酸，IHRE HERSTELLUNG UND VERWENDUNG ALS HEMMER VON RNA-VIRUSPOLYMERASEN
- 专利标题： NUCLEOSIDES PREPARATION THEREOF AND USE AS INHIBITORS OF RNA VIRAL POLYMERASES
- 专利标题（中）： 核苷酸，IHRE HERSTELLUNG UND VERWENDUNG ALS HEMMER VON RNA-VIRUSPOLYMERASEN
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申请号： EP02807245.2申请日： 2002-11-14
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公开(公告)号： EP1450809A2公开(公告)日： 2004-09-01
- 发明人: BABU, Yarlagadda, S. , CHAND, Pooran , EL-KATTAN, Yahya , WU, Minwan
- 申请人： Biocryst Pharmaceuticals, Inc.
- 申请人地址： 2910 Parkway Lake Drive Birmingham, Alabama 35244 US
- 专利权人： Biocryst Pharmaceuticals, Inc.
- 当前专利权人： Biocryst Pharmaceuticals, Inc.
- 当前专利权人地址： 2910 Parkway Lake Drive Birmingham, Alabama 35244 US
- 代理机构： Zanoli, Enrico
- 优先权： US331322P 20011114
- 国际公布： WO2003087298 20031023
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; A61K31/51 ; A61K31/513 ; A61K31/52 ; C07D239/36 ; C07D473/34
摘要：
Compounds represented by the formula: Wherein A is -(CH2)n-R, -CH=CH2, -CH2-CH=CH2, -O-(CH2)n-R, -CH(OH)CH3, -CH(OH)-CH2OH, -CH2-CH(OH)CH3, -CH2-CH(OH)-CH2OH, -CH(OH)-CH(OH)-CH3; R is H, OH, F, N3, NH2, CO2H, SH, alkyl, S-alkyl, O-acyl, CONH2, CONH-alkyl; Z and Z' independently is OR , OR , O-(CH2)n-O-alkyl or aminoacids and esters thereof; R and R independently is H, alkyl, aryl, pivaloyloxymethyl, phthalyl or substituted phthalyl, C(R )2OC(O)X(R )a, R is -H, C1-C12 alkyl, C5-C12 aryl, C2-C12 alkenyl, C2-C12 alkynyl, C7-C12 alkenylaryl, C7-C12 alkynylaryl, or C6-C12 alkaryl, any of which is unsubstituted or is substituted with 1 or 2 halo, cyano, azido, nitro, or -OR ; R is -H, C1-C12 alkyl, C5-C12 aryl, C2-C12 alkenyl, C2-C12 alkynyl, C7-C12 alkenylaryl, C7-C12 alkynylaryl, or C6-C12 alkaryl, any of which is unsubstituted or is substituted with 1 or 2 halo, cyano, azido, nitro, -N(R )2 or -OR ; R is C1-C12
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